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Mining plasmodium

  • Genome Mining-Based Identification of Identical

    Herein, we perform a novel genome mining approach to identify a pair of identical multirepeat sequences (IMRSs) that constitute 170 and 123 copies in the Plasmodium falciparum genome and explore their potential as primers for PCR.

  • Global database of matched Plasmodium falciparum and P

    Aug 18, 2015· Plasmodium falciparum (left panel) and P. vivax (right panel) records are shown as points along an axis of the study start year. The points vary in …

  • Frontiers Mining the Human Host Metabolome Toward an

    Plasmodium is a highly complex pathogen which undergoes multiple stage transitions during its passage between its invertebrate and vertebrate hosts. Further mining of the host metabolome may help to improve our understanding of the complexities that exist in the malaria host-pathogen system that enhance or hinder transmission.

  • Malaria in gold-mining areas in C preview & related

    (2016) Castellanos et al. Memorias do Instituto Oswaldo Cruz. Gold-mining may play an important role in the maintenance of malaria worldwide. Gold-mining, mostly illegal, has significantly expanded in Colombia during the last decade in areas with limited health care and disease prevention. We rep

  • Mining geographic variations of Plasmodium vivax for

    May 27, 2015· Mining geographic variations of Plasmodium vivax for active surveillance: a case study in China. Benyun Shi Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China.

  • Malaria Guide: Causes, Symptoms and Treatment Options

    May 18, 2020· Many more infected red blood cells are broken down by your spleen or liver, which filter out and remove damaged or aging red blood cells from circulation. Both Plasmodium parasites in the bloodstream and irritants that are released from broken red blood cells cause malaria symptoms.

  • [The evolution of in-vitro resistance in Plasmodium

    This study evaluates the sensitivity of P. falciparum in vitro to antimalarial drugs in an area of gold mining exploration in Amapá State during the period of 1983 to 1990. The following tests were done, 75 in vitro studies with chloroquine and quinine, 74 with amodiaquine and 76 with mefloquine. Th …

  • Performance of the hematology analyzer XN-31 prototype in

    Mar 04, 2021· Five species of the genus Plasmodium cause human infection: Plasmodium falciparum, Plasmodium vivax, Plasmodium and platinum mining. Chocó accounted for 27.3% of …

  • Tail Wags the Dog? Functional Gene Classes Driving Genome

    Mining Plasmodium ’s Genomic, Coding, GC 3, and Genic GC Content Values with CoGe Representative genomes from the four major Plasmodium clades (simian, rodents, Laverania subgenus, and birds/reptiles) were obtained from NCBI/GenBank ( Clark et al. 2016 ), PlasmoDB ( Aurrecoechea et al. 2009 ), and GeneDB ( Logan-Klumpler et al. 2012 ).

  • Antioxidant defense in Plasmodium falciparum – data mining

    The Plasmodium-infected erythrocyte is under constant oxidative stress.This is caused by exogenous reactive oxidant species (ROS) and reactive nitrogen species (RNS) produced by the immune system of the host, and by endogenous production of ROS generated during the digestion of host cell haemoglobin and concomitant biochemical reactions.

  • Mining the Plasmodium genome database to define organellar

    Apicomplexan species constitute a diverse group of parasitic protozoa, which are responsible for a wide range of diseases in many organisms. Despite differences in the diseases they cause, these parasites share an underlying biology, from the genetic controls used to differentiate through the complex parasite life cycle, to the basic biochemical pathways employed for intracellular survival, to

  • Mining the malaria transcriptome - ScienceDirect

    Aug 01, 2005· New directions from data mining. There are myriad questions posed by the available DNA microarray data that are well suited for rigorous computational examination. For example, owing to the high AT content (∼90%) in the noncoding regions of the genome, predicting gene-regulatory regions in Plasmodium is a difficult task.

  • Investigation of a possible malaria epidemic in an illegal

    Mar 22, 2019· At this mining site, PCR-Plasmodium prevalence was estimated to be 60% (15/26) (95% CI 40.8–79.2), of which 80% were asymptomatic. The malaria attack rate was estimated at 53.8% (95% CI 34.6–73] in the past 3 months but should be interpreted carefully because of memory bias, extreme mobility and excessive diagnosis of malaria in case of fever.

  • Mining geographic variations of Plasmodium vivax for

    May 27, 2015· Mining geographic variations of Plasmodium vivax for active surveillance: a case study in China. Benyun Shi 1,2, Qi Tan 3, Xiao-Nong Zhou 4 & Jiming Liu 3 Malaria Journal volume 14, Article number: 216 (2015) Cite this article

  • Genome mining offers a new starting point for parasitology

    Genome mining offers a new starting point for parasitology research Parasitol Res. 2015 Feb;114(2):399-409. doi: 10.1007/s00436-014-4299-5. Epub 2015 Jan 8. Authors Zhiyue Lv 1 Plasmodium falciparum / immunology Vaccines Substances Vaccines

  • Frontiers Mining the Human Host Metabolome Toward an

    Plasmodium is a highly complex pathogen which undergoes multiple stage transitions during its passage between its invertebrate and vertebrate hosts. Further mining of the host metabolome may help to improve our understanding of the complexities that exist in the malaria host-pathogen system that enhance or hinder transmission.

  • Evolution of Host Specificity by Malaria Parasites through

    The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and parasite. Here, we report that these selective pressures have resulted in unexpected alterations to one of the most basic aspects of eukaryotic

  • (PDF) Mining geographic variations of Plasmodium vivax for

    Mining geographic variations of Plasmodium vivax for active surveillance: A case study in. China.pdf. Content available from CC BY 4.0: 12936_2015_Article_719.pdf.

  • Malaria and Hantavirus Pulmonary Syndrome in Gold Mining

    May 25, 2019· Out of the 112 blood samples analyzed, five were positive for Plasmodium infection (four P. falciparum and one P. vivax), and four were seropositive for hantavirus, showing a seroprevalence of 3.57%. One of the four miners who was seroreactive for hantavirus concomitantly had P. falciparum infection, which was confirmed by thick blood smear.

  • Malaria database: interactions for Plasmodium falciparum

    Apr 25, 2019· Malaria database: interactions for Plasmodium falciparum proteins extracted with text mining Published on April 25, 2019 April 25, 2019 • 29 Likes • 7 Comments

  • Assessment of mercury exposure and malaria in a Brazilian

    Small-scale gold mining in the Brazilian Amazon occurs in areas with high rates of malaria transmission. Amazonian populations can be exposed to mercury through direct contact with the mining process and/or through fish consumption. Because of data from experimental studies, we examined the potentia …

  • TOOLS: Mining the Plasmodium Genome Science

    The malaria parasite, Plasmodium falciparum , has for decades frustrated researchers trying to understand everything from its biochemistry to the function of its genes. A new site featuring data from the Malaria Genome Project, however, offers researchers a powerful collection of tools for mining data and new insights into this leading enemy of public health.

  • Malaria in Southern Venezuela: The hottest hotspot in

    Jan 25, 2021· Malaria risk was highly focal and prevalent in 2 consistent disease hotspots that accounted for most Plasmodium transmission in the whole region. Illegal gold-mining activities seem to drive malaria in these disease pockets and seem critical in malaria's surge throughout the country.

  • Plasmodium vivax readiness to transmit: implication for

    Jan 11, 2019· The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. vivax human infections, we used Next Generation Sequencing data mining to unravel parasite in vivo expression profiles for P. vivax, and P. falciparum as comparison.

  • Plasmodium - Wikipedia

    Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.The life cycles of Plasmodium species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue (often the liver) before entering the bloodstream to infect red blood cells.

  • Mining Sudanese Medicinal Plants for Antiprotozoal Agents

    Mining Sudanese Medicinal Plants for Antiprotozoal Agents Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria.

  • Mining the Plasmodium genome database to define organellar

    Jan 29, 2002· The Plasmodium Genome Database (PlasmoDB) has been designed to permit individual investigators to ask their own questions, even prior to formal release of the reference P. falciparum genome sequence.

  • Genome Mining–Based Identification of Identical

    Sep 01, 2019· Herein, we perform a novel genome mining approach to identify a pair of identical multirepeat sequences (IMRSs) that constitute 170 and 123 copies in the Plasmodium falciparum genome and explore their potential as primers for PCR.

  • Mining the Plasmodium genome database to define organellar

    Jan 01, 2002· Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? David S Roos , Michael J Crawford , Robert G K Donald , Martin Fraunholz , Omar S Harb , Cynthia Y He , Jessica C Kissinger , Michael K Shaw , and Boris Striepen

  • Malaria in gold-mining areas in Colombia

    Key words: mining; malaria; Plasmodium vivax; Plasmodium falciparum; gold Mining has historically played an important role in the expansion and creation of many productive human settlements and to the national economy of mineral rich countries, but simultaneously it has led to an increase in malaria transmission in mining areas ( Knoblauch et

  • Malaria and Hantavirus Pulmonary Syndrome in Gold Mining

    May 25, 2019· Out of the 112 blood samples analyzed, five were positive for Plasmodium infection (four P. falciparum and one P. vivax), and four were seropositive for hantavirus, showing a seroprevalence of 3.57%. One of the four miners who was seroreactive for hantavirus concomitantly had P. falciparum infection, which was confirmed by thick blood smear.

  • A zoonotic human infection with simian malaria, Plasmodium

    Apr 16, 2016· A case of Plasmodium knowlesi infection in a worker from a charcoal mining company in Central Kalimantan, Indonesia was described. The worker suffered from fever following his visit to a lowland forest being cut and converted into a new mining location.

  • Prevalence of Plasmodium spp. in illegal gold miners in

    The 68 mining sites of origin were grouped in ten areas according to proximity and river basin. Prevalence varied from 3.8 to 46.4 % with a higher prevalence in the region located between Maripa Soula and Saül (Fig. 1). Distribution of asymptomatic persons or Plasmodium …

  • Compositions and Methods for Blocking Transmission of

    Compositions and Methods for Blocking Transmission of Plasmodium According to the World Health Organization, about 3.2 billion people – nearly half of the world's population – are at risk of infection by Plasmodium parasites, resulting in malaria.

  • The Multifaceted Role of Protein Phosphatase 1 in Plasmodium

    Feb 01, 2021· Recently, with the massive technological improvement of reverse genetics, multi-omics tools, as well as the availability of databases to speed up data mining, major breakthroughs have been achieved in deciphering the role of phosphatases in the Plasmodium life cycle. Functional screens and characterization of engineered parasite lines led to the identification of crucial phospho-signaling

  • Plasmodium falciparum Apn1 homolog is a mitochondrial base

    DNA repair mechanism (s) operative within these organelles were explored by mining the Plasmodium falciparum nuclear genome for sequences encoding proteins of major DNA repair pathways with predicted targeting to either organelle.

  • Investigation of a possible malaria epidemic in an illegal

    Mar 22, 2019· Endemic species are Plasmodium falciparum and Plasmodium vivax, transmitted mainly by Anopheles darlingi [ 2 ]. However, undetected by the surveillance system (which is based on passive case detection at health care facilities), a silent but massive endemic transmission still occurs in illegal gold mining areas deep inside the forest [ 3, 4 ].

  • plasmodium - members.cbio.mines-paristech

    plasmodium October 12, 2009 References [1] Z. Bozdech and H. Ginsburg. Antioxidant defense in Plasmodium falci-parum - data mining of the transcriptome.

  • Plasmodium development in the mosquito: biology

    Quantitative analyses of malaria parasite development are necessary to assess the efficacy of control measures. Such analyses in the mammalian host have been difficult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmission-blocking strategies. Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host.

  • (PDF) Data mining of the transcriptome of Plasmodium

    Data mining of the transcriptome of Plasmodium falciparum: The pentose phosphate pathway and ancillary pro. cesses.pdf. Content available from CC BY 2.0: 1475-2875-4-17.pdf.

  • Kinetics of Plasmodium midgut invasion in Anopheles …

    million deaths [1]. Malaria-causing Plasmodium parasites are transmitted by Anopheles mos- quitoes. Among more than 400 of known Anopheles species, only 40 are vectors of human malaria [2]. Plasmodium development in the mosquito begins with the ingestion of red blood cells infected with sexual-stage gametocytes. In the mosquito midgut, gametocytes differentiate into

  • Mining the Plasmodium genome database to define organellar

    Jan 29, 2002· Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? David S Roos , Michael J Crawford , Robert G K Donald , Martin Fraunholz , Omar S Harb , Cynthia Y He , Jessica C Kissinger , Michael K Shaw , and Boris Striepen

  • Malaria in gold-mining areas in Colombia

    In countries like Ghana, the overall malaria prevalence was 22.8% in 2006/2007, with ~98% in mining areas that were predominantly Plasmodium falciparum infections (Asante et al. 2011), meanwhile in PNG (Lihir Island) Plasmodium vivax was more prevalent (57%) in 2006-2011, with a small number of Plasmodium malariae cases (< 3%) (Mitjà et al. 2013).

  • Thailand: Malaria IAMAT

    Incidence of Plasmodium falciparum Malaria: > 50% Of the five species of human malaria parasites, Plasmodium falciparum is the most dangerous. The remaining percentage represents malaria infections that may be caused by one or more of the following parasites: Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi.